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Role, Laboratory Assessment and Clinical Relevance of Fibrin, Factor XIII and Endogenous Fibrinolysis in Arterial and Venous Thrombosis.

Int J Mol Sci. 2021 Feb 02;22(3)
Vassilios P Memtsas 1 , Deepa R J Arachchillage 2 , Diana A Gorog 3
Vassilios P Memtsas 1 , Deepa R J Arachchillage 2 , Diana A Gorog 3

[No authors listed]

Author information
  • 1 Cardiology Department, East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire SG1 4AB, UK.
  • 2 Department of Haematology, Royal Brompton Hospital, London SW3 6NP, UK.
  • 3 Faculty of Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK.

摘要


Diseases such as myocardial infarction, ischaemic stroke, peripheral vascular disease and venous thromboembolism are major contributors to morbidity and mortality. Procoagulant, anticoagulant and fibrinolytic pathways are finely regulated in healthy individuals and dysregulated procoagulant, anticoagulant and fibrinolytic pathways lead to arterial and venous thrombosis. In this review article, we discuss the (patho)physiological role and laboratory assessment of fibrin, factor XIII and endogenous fibrinolysis, which are key players in the terminal phase of the coagulation cascade and fibrinolysis. Finally, we present the most up-to-date evidence for their involvement in various disease states and assessment of cardiovascular risk.

KEYWORDS: coagulation, endogenous fibrinolysis, factor XIII, fibrin, thrombosis