Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice.
Cell Rep. 2020 Dec 15;33(11):108507
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摘要
The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting that the innate immune system limits the regenerative response to injury.
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基因功能
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原始数据
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文献解读
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