Transcription factor ChREBP â the coordinator of carbohydrate and lipid metabolism
Postepy Biochem. 2020 Jan 09;66(1):30-37. doi:10.18388/pb.2019_282
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摘要
Transcription factor ChREBP, in complex with MLX, binds to carbohydrate-response element (ChoRE) located in the promoters of genes related to glycolysis, gluconeogenesis, pentosephosphate pathway and lipogenesis, activating their transcription following stimulation with glucose, insulin-independently. In this article the mechanisms of ChREBP regulation and ChREBP functions under both physiological and pathophysiological conditions are described in detail. The possible use of ChREBP activity modulation as a therapeutic tool, e.g. in case of nonalcoholic fatty liver disease, diabetes type 2 and cancers, is also discussed.
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基因功能
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原始数据
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文献解读
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