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Overlaps, gaps, and complexities of mouse models of Developmental and Epileptic Encephalopathy.

Neurobiol Dis. 2021 Jan;148:105220. Epub 2020 Dec 07
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摘要


Mouse models have made innumerable contributions to understanding the genetic basis of neurological disease and pathogenic mechanisms and to therapy development. Here we consider the current state of mouse genetic models of Developmental and Epileptic Encephalopathy (DEE), representing a set of rare but devastating and largely intractable childhood epilepsies. By examining the range of mouse lines available in this rapidly moving field and by detailing both expected and unusual features in representative examples, we highlight lessons learned in an effort to maximize the full potential of this powerful resource for preclinical studies. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

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