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Serum Neuropeptide Y Level is Associated with Post-Ischemic Stroke Epilepsy.

J Stroke Cerebrovasc Dis. 2021 Feb;30(2):105475. Epub 2020 Nov 23
Nuan Wang 1 , Dongxing Wang 2 , Hao Zhou 3 , Cuifu Xu 3 , Xiaowei Hu 4 , Zhiyuan Qian 5 , Xingshun Xu 6
Nuan Wang 1 , Dongxing Wang 2 , Hao Zhou 3 , Cuifu Xu 3 , Xiaowei Hu 4 , Zhiyuan Qian 5 , Xingshun Xu 6
+ et al

[No authors listed]

Author information
  • 1 Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou City, 215004, China; Department of Neurology, Affiliated Hospital of China University of Mining and Technology, Xuzhou City, 221116, China.
  • 2 Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou City, 215004, China.
  • 3 Department of Neurology, Affiliated Hospital of China University of Mining and Technology, Xuzhou City, 221116, China.
  • 4 Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou City, 215006, China. Electronic address: huxiaowei@suda.edu.cn.
  • 5 Department of Neurosurgy, the First Affiliated Hospital of Soochow University, Suzhou City, 215006, China. Electronic address: zhiyuanqian@suda.edu.cn.
  • 6 Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou City, 215004, China; Institute of Neuroscience, Soochow University, Suzhou City, 215123, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou City, Jiangsu 215123, China. Electronic address: xingshunxu@suda.edu.cn.

摘要

BACKGROUND AND PURPOSE:Post-ischemic stroke epilepsy (PISE) is one of the common complications of stroke. MATERIALS AND METHODS:Methods To determine the risk factors of PISE, in this study, 78 patients with PISE and 86 patients without PISE were recruited. Clinical data and serum neuropeptide Y (NPY) levels were collected and the relative factors including clinical data and serum were analyzed. RESULTS:Logistic regression showed that low serum NPY was significantly associated with PISE. Every 5 ng/ml increment of serum NPY was associated with 62% risk decrease in patients with PISE. The area under curve of serum NPY was 0.910 with a sensitivity of 84.62% and a specificity of 86.05%. The cut-off value of serum NPY was 90 ng/ml. According to cut-off value of serum NPY, the percentage of patients with PISE decreased from 84.6% in low serum NPY group to 14.0% in high serum NPY group. Furthermore, patients were divided into different tertiles according to serum NPY. The percentage of patients with PISE reduced from 90.0% in the lowest tertile (NPY < 85 ng/ml) to 3.5% in the highest tertile (NPY ≥ 105 ng/ml). Compared with patients with normal video-electroencephalogram (VEEG), serum NPY levels significantly decreased in patients with abnormal VEEG; however, serum NPY levels were not associaated with epileptic seizure subtypes. CONCLUSIONS:Serum NPY was an independent risk factor for PISE. Targeting serum NPY may be used to the prevention and treatment of PISE.

KEYWORDS: NPY, Post-ischemic stroke epilepsy, Risk factor, Seizure, Stroke

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