The methyltransferase SETD3-mediated histidine methylation: Biological functions and potential implications in cancers.
Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188465. Epub 2020 Nov 04
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摘要
SETD3 belongs to a family of SET-domain containing proteins. Recently, SETD3 was found as the first and so-far the only known metazoan histidine methyltransferase that catalyzes actin histidine 73 (His73) methylation, a pervasive modification which was discovered more than 50Â years ago. In this review, we summarize some recent advances in SETD3 research, focusing on structural properties, substrate-recognition features, and physiological functions. We particularly highlight potential pathological relevance of SETD3 in human cancers and raise some questions to promote discussion about this novel histidine methyltransferase.
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基因功能
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原始数据
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文献解读
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