Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1.
Dokl Biochem Biophys. 2020 Sep;494(1):244-247. Epub 2020 Oct 20
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摘要
Previously, we designed and synthesized dipeptide mimetics of individual loops of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF). It was shown that these mimetics activate the corresponding tyrosine kinase (Trk) receptors and have different patterns of activation of the PI3K/AKT and MAPK/ERK postreceptor signaling pathways in vitro. In the present study, it was shown on HT-22 cells that all these compounds activate the phospholipase C-γ1 (PLC-γ1) cascade.
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基因功能
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原始数据
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文献解读
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