Intracellular Transport of Ribosome-Inactivating Proteins Depends on Annexin 13.
Dokl Biochem Biophys. 2020 Sep;494(1):219-221. Epub 2020 Oct 20
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摘要
In the present study, we assessed the role of annexin 13 membrane-binding protein (ANXA13) in the intracellular transport of vesicles containing type II ribosome-inactivating proteins (RIP-IIs). A modified human intestinal epithelial cell line HT29 was used, in which the expression of ANXA13 was significantly reduced. The cytotoxic effect of ricin and viscumin was evaluated by modification of 28S ribosome RNA. The observed differences in the activity of toxins on the parental and modified HT29 lines indicate that ANXA13 plays a different role in the intracellular transport of vesicles containing the RIP-IIs.
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基因功能
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原始数据
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文献解读
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