The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.
JACC Basic Transl Sci. 2021 Jan;6(1):1-8. Epub 2020 Oct 16
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摘要
Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting angiotensin-converting enzyme-2 (ACE2) binding with the SARS-CoV-2 spike protein. This work focuses on the potential to inhibit SARS-CoV-2 entry through a hypothesized α5β1 integrin-based mechanism and indicates that inhibiting the spike protein interaction with α5β1 integrin (+/- ACE2) and the interaction between α5β1 integrin and ACE2 using a novel molecule (ATN-161) represents a promising approach to treat coronavirus disease-19.
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基因功能
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原始数据
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文献解读
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