例如:"lncRNA", "apoptosis", "WRKY"

The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.

Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118895. Epub 2020 Oct 21
Dan-Ni Li 1 , Cheng-Cheng Yang 2 , Jin Li 3 , Qiu-Geng Ou Yang 2 , Lv-Tao Zeng 3 , Guo-Qing Fan 3 , Teng-Hui Liu 2 , Xin-Yuan Tian 1 , Jing-Jing Wang 1 , He Zhang 3 , Da-Peng Dai 3 , Ju Cui 3 , Jian-Ping Cai 4
Dan-Ni Li 1 , Cheng-Cheng Yang 2 , Jin Li 3 , Qiu-Geng Ou Yang 2 , Lv-Tao Zeng 3 , Guo-Qing Fan 3 , Teng-Hui Liu 2 , Xin-Yuan Tian 1 , Jing-Jing Wang 1 , He Zhang 3 , Da-Peng Dai 3 , Ju Cui 3 , Jian-Ping Cai 4
+ et al

[No authors listed]

Author information
  • 1 Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, PR China.
  • 2 School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • 3 The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, NO.1 DaHua Road, Dong Dan, Beijing 100730, PR China.
  • 4 Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, PR China; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, NO.1 DaHua Road, Dong Dan, Beijing 100730, PR China. Electronic address: caijp61@vip.sina.com.

摘要


MutT Homolog 1 (MTH1) is a mammalian 8-oxodGTPase for sanitizing oxidative damage to the nucleotide pool. Nudix type 5 (NUDT5) also sanitizes 8-oxodGDP in the nucleotide pool. The role of MTH1 and NUDT5 in non-small-cell lung cancer (NSCLC) progression and metastasis remains unclear. In the present study, we reported that MTH1 and NUDT5 were upregulated in NSCLC cell lines and tissues, and higher levels of MTH1 or NUDT5 were associated with tumor metastasis and a poor prognosis in patients with NSCLC. Their suppression also restrained tumor growth and lung metastasis in vivo and significantly inhibited NSCLC cell migration, invasion, cell proliferation and cell cycle progression while promoting apoptosis in vitro. The opposite effects were observed in vitro following MTH1 or NUDT5 rescue. In addition, the upregulation of MTH1 or NUDT5 enhanced the MAPK pathway and PI3K/AKT activity. Furthermore, MTH1 and NUDT5 induce epithelial-mesenchymal transition both in vitro and in vivo. These results highlight the essential role of MTH1 and NUDT5 in NSCLC tumor tumorigenesis and metastasis as well as their functions as valuable markers of the NSCLC prognosis and potential therapeutic targets.

KEYWORDS: Cancer progression, MTH1, Metastasis, NUDT5, Non-small-cell lung cancer