Mysterious and fascinating: DNA polymerase É© remains enigmatic 20 years after its discovery.

DNA Repair (Amst). 2020 Sep;93:102914

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摘要

With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polÉ©), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polÉ© remains unknown. Here, we provide a graphical review of the unique biochemical properties of polÉ© and speculate about the cellular pathways in which enigmatic polÉ© may participate.

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Mysterious and fascinating: DNA polymerase É© remains enigmatic 20 years after its discovery.

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