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A curious case of cysteines in human peroxiredoxin I.

Redox Biol. 2020 Oct;37:101738. Epub 2020 Sep 24
Ashu Mohammad 1 , Reena V Saini 2 , Rakesh Kumar 3 , Deepak Sharma 3 , Neeraj K Saini 4 , Arpit Gupta 3 , Priyanka Thakur 5 , Christine C Winterbourn 6 , Adesh K Saini 7
Ashu Mohammad 1 , Reena V Saini 2 , Rakesh Kumar 3 , Deepak Sharma 3 , Neeraj K Saini 4 , Arpit Gupta 3 , Priyanka Thakur 5 , Christine C Winterbourn 6 , Adesh K Saini 7
+ et al

[No authors listed]

Author information
  • 1 Department of Biotechnology and Central Research Cell, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India; Faculty of Applied Science and Biotechnology, Shoolini University, Solan, 173229, India.
  • 2 Department of Biotechnology and Central Research Cell, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India.
  • 3 Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India.
  • 4 Department of Biotechnology, Jawaharlal Nehru University, Delhi, 110067, India.
  • 5 Faculty of Sciences, Shoolini University, Solan, 173229, India.
  • 6 Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
  • 7 Department of Biotechnology and Central Research Cell, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India; Maharishi Markandeshwar (Deemed to Be University), Solan, HP, 173212, India. Electronic address: sainiade@mmumullana.org.

摘要

was resistant to hyperoxidation and formation of stable high molecular weight oligomers, which is suggestive of impaired chaperone activity. Our results suggest that the catalytic residues of hPrxI are essential to counter the nitrosative stress whereas Cys83 in hPrxI plays a critical role in hyperoxidation of hPrxI.

KEYWORDS: Catalytic residues, Chaperone activity, Human peroxiredoxins, Redox stress, Saccharomyces cerevisiae, Yeast

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