[Retrovirus Restriction Factor TRIM5Î±: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection].

Mol Biol (Mosk). 2020 Sep-Oct ;54(5):707-717. doi:10.31857/S0026898420050031

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It is commonly known that the antiviral activity of the TRIM5Î± protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5Î± can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5a protein and the prospects for using it in gene therapy of HIV infection.

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[Retrovirus Restriction Factor TRIM5Î±: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection].

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