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Differential Expression of E-Cadherin and P-Cadherin in Breast Cancer Molecular Subtypes.

Anticancer Res. 2020 Oct;40(10):5557-5566
Madalin Marius Margan 1 , Anca Maria Cimpean 2 , Amalia Raluca Ceausu 2 , Marius Raica 2
Madalin Marius Margan 1 , Anca Maria Cimpean 2 , Amalia Raluca Ceausu 2 , Marius Raica 2

[No authors listed]

Author information
  • 1 Doctoral School, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
  • 2 Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

摘要


BACKGROUND/AIM:E- and P-cadherin (E-cadh, P-cadh) control tumor cell invasion, metastatic or stemness potential and chemotherapy resistance. The study aimed to assess E- and P-cadherin expression in breast cancer molecular subtypes. MATERIALS AND METHODS:Immunohistochemistry for E-cadh and P-cadh was performed for 97 breast cancer cases. Membrane (M), cytoplasmic (C) or mixed (MC) patterns of E-cadh and P-cadh were considered in our evaluation. RESULTS:E-cadh and P-cadh C pattern was significantly correlated in the HER2 subtype (p=0.031). P-cadh M pattern was highly specific for the HER2 subtype (p=0.002). Only P-cadh C characterized the triple negative breast cancer subtype (p=0.015). For Luminal B/HER2 cases, P-cadh M pattern was strongly coexpressed with the E-cadh MC pattern (p=0.012). Progesterone receptor (PR) expression influenced E-cadh M pattern in the Luminal B/HER2 subtype (p=0.042). CONCLUSION:E- and P-cadherins define distinct subgroups within breast cancer molecular subtypes. Our findings support the inclusion of E- and P-cadherin into breast cancer molecular classification.

KEYWORDS: Breast cancer, E-cadherin, P-cadherin, molecular subtypes