[No authors listed]
Geriatric frailty is associated with increased mortality and links to increased inflammatory activity. Vascular adhesion protein-1 (VAP-1) is important in inflammatory process. This study investigates the relationship between plasma VAP-1 level and frailty in older adults.The cross-sectional study recruited community dwelling older adults from a hospital-based comprehensive geriatric assessment program. The demographic data, Fried Frailty Index, metabolic and inflammatory parameters were assessed.A total of 151 participants (76 women, 50.3%) were included in the analysis, and the age (meanâ±â standard deviation) was 77.1â±â6.1 years. The mean plasma VAP-1 level (ng/mL) was significantly different (Pâ=â.029) among different frailty groups (346.3â±â86.5 in the robust older adults, 371.6â±â107.9 in the pre-frail older adults, and 416.6â±â141.1 in the frail older adults). Multivariate ordered logistic regression analysis also demonstrated that plasma VAP-1 levels were positively associated with frailty severity (Pâ=â.039). Analysis of the frailty components with plasma VAP-1 levels showed that the elderly who had "exhaustion" (Pâ=â.016) or "weakness" (Pâ=â.025) tended to have higher plasma VAP-1 levels.The data support that VAP-1 might represent a potential plasma biomarker of frailty.
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