Alternative splicing of leptin receptor overlapping transcript in osteosarcoma.
Exp Biol Med (Maywood). 2020 Oct;245(16):1437-1443. doi:10.1177/1535370220949139. Epub 2020 Aug 12
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摘要
IMPACT (OS, also known as osteogenic sarcoma) is the most common primary malignancy of bone in children and adolescents. The molecular mechanisms of OS are extremely complicated and its molecular mediators remain to be elucidated. We sequenced total RNA from 18 OS bone samples (paired normal-tumor biopsies). We found statistically significant (FDR <0.05) 26 differentially expressed transcript variants of LEPROT gene with different expressions in normal and tumor samples. These findings contribute to the understanding of molecular mechanisms of OS development and provide encouragement to pursue further research.
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基因功能
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原始数据
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文献解读
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