Lysine-specific histone demethylase 1A (LSD1) in cervical cancer.
[No authors listed]
摘要
PURPOSE:Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use. METHODS:Tumor samples of 250 cervical cancer patients were immunochemically stained and evaluated based on Immunoreactive Results were statistically analyzed for clinical and pathological parameters. RESULTS:Our patient collective showed a disadvantage for 10-year survival for patients with a strong expression of LSD1 in the cytoplasm of cervical cancer cells. The results of the correlational analysis further revealed a negative correlation of LSD1 to G-protein coupled estrogen receptor (GPER). CONCLUSIONS:Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations.
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基因功能
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原始数据
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文献解读
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