Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model.

Nat Commun. 2020 Jul 27;11(1):3753

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Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1Î±, TNFÎ±, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the SOD1^G93A ALS mouse model, providing evidence for gliosis as a potential ALS therapeutic target.

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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model.

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