例如："lncRNA", "apoptosis", "WRKY"

Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.

Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19425-19434. Epub 2020 Jul 27
Can Wang 1 , Zhiting Wang 1 , Meiling He 1 , Tiantian Zhou 1 , Yayan Niu 2 , Shengxuan Sun 3 , Hui Li 1 , Ce Zhang 1 , Shengnan Zhang 1 , Meng Liu 1 , Ying Xu 4 , Ningzheng Dong 2 , Qingyu Wu 5
Can Wang 1 , Zhiting Wang 1 , Meiling He 1 , Tiantian Zhou 1 , Yayan Niu 2 , Shengxuan Sun 3 , Hui Li 1 , Ce Zhang 1 , Shengnan Zhang 1 , Meng Liu 1 , Ying Xu 4 , Ningzheng Dong 2 , Qingyu Wu 5
+ et al

[No authors listed]

Author information
  • 1 Cyrus Tang Hematology Center, Ministry of Education Engineering Center of Hematological Diseases, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, 215123 Suzhou, China.
  • 2 Ministry of Health Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, 215006 Suzhou, China.
  • 3 Department of Orthopedics, The Second Affiliated Hospital of Soochow University, 215004 Suzhou, China.
  • 4 Cambridge-Soochow University Genomic Resource Center, Soochow University, 215123 Suzhou, China.
  • 5 Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.

摘要

Spiral artery remodeling is an important physiological process in the pregnant uterus which increases blood flow to the fetus. Impaired spiral artery remodeling contributes to preeclampsia, a major disease in pregnancy. Corin, a transmembrane serine protease, is up-regulated in the pregnant uterus to promote spiral artery remodeling. To date, the mechanism underlying uterine corin up-regulation remains unknown. Here we show that Krüppel-like factor (KLF) 17 is a key transcription factor for uterine corin expression in pregnancy. In cultured human uterine endometrial cells, KLF17 binds to the CORIN promoter and enhances the promoter activity. Disruption of the KLF17 gene in the endometrial cells abolishes CORIN expression. In mice, Klf17 is up-regulated in the pregnant uterus. Klf17 deficiency prevents uterine Corin expression in pregnancy. Moreover, Klf17-deficient mice have poorly remodeled uterine spiral arteries and develop gestational hypertension and proteinuria. Together, our results reveal an important function of KLF17 in regulating Corin expression and uterine physiology in pregnancy.

KEYWORDS: KLF17, corin, pregnancy

© 2017 biocloud.net版权所有 ICP证：京10042835号