prostate cancer: An aggressive cancer subtype prevalent in African American patients.
Prostate. 2020 Sep;80(13):1045-1057. doi:10.1002/pros.24018. Epub 2020 Jul 20
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摘要
BACKGROUND:There is a need to develop novel therapies which could be beneficial to patients with prostate cancer (CaP) including those who are predisposed to poor outcome, such as African-Americans. This study investigates the role of ROBO1-pathway in predicting outcome and race-based disparity in patients with CaP. METHODS AND RESULTS: Zebrafish model. CONCLUSION:We suggest that ROBO1 status forms as predictive biomarker of outcome in high-risk populations such as African-Americans and DOCK1-targeting therapy has a clinical potential for treating metastatic-CaP.
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基因功能
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原始数据
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文献解读
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