Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells.
Am J Physiol Gastrointest Liver Physiol. 2020 Sep 01;319(3):G323-G332. doi:10.1152/ajpgi.00178.2020. Epub 2020 Jul 20
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摘要
The findings of this study show, for the first time, that the membrane transporter of vitamin B1, i.e., thiamin transporter-1 (THTR-1), is subject to regulation by microRNAs (specifically miR-200a-3p) in mouse and human primary pancreatic acinar cells (PACs). The results also show that this posttranscriptional regulation has functional consequences on the ability of PACs to take in the essential micronutrient thiamin.
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基因功能
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原始数据
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文献解读
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