The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19.
[No authors listed]
摘要
Ruxolitinib is the first approved JAK1 and JAK2 inhibitor, and is known to interfere with the JAK / signaling pathway, one of the critical cellular signaling pathways involved in the inflammatory response. This review presents an overview of SARS-CoV-2 and the COVID-19 pandemic, and then focuses on the potential efficacy of ruxolitinib in this infection. The potential targets of ruxolitinib were determined by using genetic alterations that have been reported in COVID-19 patients. The potential effectiveness of ruxolitinib is suggested by evaluating the interactions of these potential targets with ruxolitinib or pathway. Copyright © 2020 Elsevier Ltd. All rights reserved.
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基因功能
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原始数据
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文献解读
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