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Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.

Elife. 2020 Jul 07;9
Ambuj Upadhyay 1 , Aidan J Peterson 1 , Myung-Jun Kim 1 , Michael B O'Connor 1
Ambuj Upadhyay 1 , Aidan J Peterson 1 , Myung-Jun Kim 1 , Michael B O'Connor 1

[No authors listed]

Author information
  • 1 Department of Genetics, Cell Biology and Development University of Minnesota, Minneapolis, United States.

摘要


Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages. © 2020, Upadhyay et al.

KEYWORDS: D. melanogaster, Myoglianin, Myostatin, developmental biology, growth factors, imaginal disc, muscle fiber, tgf beta