Tartryl-CoA inhibits succinyl-CoA synthetase.

Acta Crystallogr F Struct Biol Commun. 2020 Jul 01;76(Pt 7):302-308. Epub 2020 Jul 01

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Succinyl-CoA synthetase (SCS) catalyzes the only substrate-level phosphorylation step in the tricarboxylic acid cycle. Human GTP-specific SCS (GTPSCS), an Î±Î²-heterodimer, was produced in Escherichia coli. The purified protein crystallized from a solution containing tartrate, CoA and magnesium chloride, and a crystal diffracted to 1.52âÃ resolution. Tartryl-CoA was discovered to be bound to GTPSCS. The CoA portion lies in the amino-terminal domain of the Î±-subunit and the tartryl end extends towards the catalytic histidine residue. The terminal carboxylate binds to the phosphate-binding site of GTPSCS.

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Tartryl-CoA inhibits succinyl-CoA synthetase.

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