例如:"lncRNA", "apoptosis", "WRKY"

Generation of Pecam1 endothelial specific dual reporter mouse model.

Genesis. 2020 Sep;58(9):e23384. doi:10.1002/dvg.23384. Epub 2020 Jul 03
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摘要


Endothelial cells are specialized epithelium lining the interior surface of vessels and play fundamental roles in angiogenesis, vascular permeability, and immune response. To identify endothelial cells in vivo, we constructed a Pecam1nlacZ-H2B-GFP/+ knock-in mouse model in which the endothelial cells are labeled by nuclear LacZ (nlacZ) expression. When Pecam1nlacZ-H2B-GFP/+ mice are bred with germline Cre deleter mice, Pecam1H2B-GFP/+ line is created with native nuclear GFP (H2B-GFP) expression in the endothelium of various organs. This dual reporter mouse provides us with a powerful genetic tool for definitive identification of endothelial cells and monitoring this important cell population throughout development, homeostasis, and disease conditions in mammals.

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原始数据


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