MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes.

Am J Physiol Cell Physiol. 2020 Aug 01;319(2):C432-C440. doi:10.1152/ajpcell.00172.2020. Epub 2020 Jul 01

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myoblasts. The observed decline in protein synthesis was, however, not associated with a suppression of the MTOR protein but of its regulatory associated protein of mTOR complex 1 (RPTOR). These results demonstrate that modulating the expression levels of a miRNA can regulate protein synthesis in human muscle cells and provide a potential mechanism for muscle wasting in vivo.

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MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes.

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