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COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential.

Clin Immunol. 2020 Sep;218:108516. Epub 2020 Jun 20
Yujie Jiang 1 , Xin Wei 2 , Jingjing Guan 1 , Shuang Qin 1 , Zhongyong Wang 1 , Hong Lu 1 , Jingjing Qian 1 , Lianfeng Wu 1 , Yingxiao Chen 3 , Yanfan Chen 4 , Xiangyang Lin 5
Yujie Jiang 1 , Xin Wei 2 , Jingjing Guan 1 , Shuang Qin 1 , Zhongyong Wang 1 , Hong Lu 1 , Jingjing Qian 1 , Lianfeng Wu 1 , Yingxiao Chen 3 , Yanfan Chen 4 , Xiangyang Lin 5
+ et al

[No authors listed]

Author information
  • 1 Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • 2 Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
  • 3 Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou, Medical University, Wenzhou 325000, China.
  • 4 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: chenyf2605@163.com.
  • 5 Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: linxy1968@126.com.

摘要


BACKGROUND:Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8+ T and NK cells in COVID-19 patients. METHODS:The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. RESULTS:As the disease progression in COVID-19 patients, CD8+ T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8+ T and NK cells restored to some extent. GrA+CD8+ T and perforin+ NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19. CONCLUSIONS:As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19.

KEYWORDS: CD8(+) T cells, COVID-19, Granzyme, NK cells, Perforin