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Circulating miR-106b-5p serves as a diagnostic biomarker for asymptomatic carotid artery stenosis and predicts the occurrence of cerebral ischemic events.

Vasc Med. 2020 Oct;25(5):436-442. doi:10.1177/1358863X20929424. Epub 2020 Jun 19
Tao Zhang 1 , Zhiming Chen 1 , Xiaowen Yang 2 , Rui Fu 1 , Jing Wang 3 , Hang Xu 4
Tao Zhang 1 , Zhiming Chen 1 , Xiaowen Yang 2 , Rui Fu 1 , Jing Wang 3 , Hang Xu 4
+ et al

[No authors listed]

Author information
  • 1 Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
  • 2 Department of Clinical Laboratory, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
  • 3 Department of Nuclear Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
  • 4 Department of Health Management, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

摘要


This study aimed to investigate the expression and diagnostic value of miR-106b-5p in asymptomatic carotid artery stenosis (CAS) patients, and further explore its predictive value for the occurrence of cerebral ischemic events (CIE). A total of 58 asymptomatic CAS cases and 61 healthy controls were recruited. Quantitative RT-PCR was applied for the measurement of the miR-106b-5p level. The receiver operating characteristic (ROC) curve was plotted to assess the diagnostic value of miR-106b-5p for CAS. Kaplan-Meier methods and Cox regression analysis were performed to assess the predictive value of miR-106b-5p for the occurrence of CIE. In patients with asymptomatic CAS, miR-106b-5p was highly expressed. The miR-106b-5p level showed a significant association with dyslipidemia, hypertension, and the degree of carotid stenosis. miR-106b-5p had a relative accuracy in differentiating patients with asymptomatic CAS from healthy individuals, with a sensitivity of 89.7% and specificity of 83.6% at the cutoff value of 0.198. Patients with high miR-106b-5p expression experienced more CIE. miR-106b-5p was highly expressed in patients with asymptomatic CAS. Our present results provide evidence for miR-106b-5p as a promising biomarker for CAS diagnosis, and for predicting the risk of future CIE in patients with asymptomatic CAS.

KEYWORDS: asymptomatic carotid artery stenosis, biomarkers, cerebral ischemic events, miR-106b-5p