Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C>A CYP1A2 genotypes.

The purpose of this study was to investigate whether variations in 163 C>A CYP1A2 genotypes (rs 762551) (AA, AC and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility and endurance in adolescent athletes. METHODS:One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg^-1 ) or placebo (PLA, 300 mg of cellulose) one hour before performing a sequence of physical tests: handgrip strength, vertical jumps, agility test, sit-ups, push-ups and the Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1). RESULTS:Compared to PLA, CAF enhanced (p < 0.05) sit-up (CAF = 37 ± 9; PLA = 35 ± 8 repetitions) and push-up repetitions (CAF = 26 ± 11; PLA = 24 ± 11 repetitions), and increased distance covered in Yo-Yo IR1 test (CAF = 1010.4 ± 378.9; PLA = 903.2 ± 325.7 m). There was no influence of CAF on handgrip strength (CAF = 35.1 ± 8.9; PLA = 33.7 ± 8.7 kgf), countermovement jump height (CAF = 49.3 ± 12.6; PLA = 47.9 ± 13.8 cm), spike jump height (CAF = 54.2 ± 13.6; PLA = 52.9 ± 14.5 cm), and time in agility test (CAF = 15.8 ± 1.1; PLA = 15.9 ± 1.3 s, p > 0.05). When present, the ergogenic effect of CAF was not dependent of genotype. CONCLUSION:CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C>A CYP1A2 genotype.

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