Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly.

J Cell Sci. 2020 Jun 24;133(12)

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deletion leads to cilia loss, RGP mislocalization, junctional integrity disruption, massive heterotopia and severe cerebellar hypoplasia. Together, these findings indicate that complete CPAP loss leads to severe and complex phenotypes in developing mouse brain, and provide new insights into the causes of MCPH.

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Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly.

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