Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish.
EMBO Rep. 2020 Jul 03;21(7):e50287. doi:10.15252/embr.202050287. Epub 2020 Jun 04
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摘要
fish were smaller in size and showed abnormal fat deposition and decreased female fertility. These physiological phenotypes were rescued by doubling the food supply, which correlated with improved bioenergetics and alterations in the metabolic gene expression program. These results reveal that SC assembly by Scaf1 modulates OXPHOS efficiency and allows the optimization of metabolic resources.
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基因功能
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原始数据
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文献解读
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