Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer.

Tetraspanin protein family forms a family of transmembrane proteins that act as organizers/scaffold for other proteins. are primarily present on plasma membranes although they are also found in other biological membranes. They are organized in tetraspanin-enriched microdomains (TEMs), which allow spatiotemporal tuning of protein functions through the control of their membrane localization. and are close paralogs expressed in different tissues, Tduanyu1842N7 being highly expressed in the brain. Their functions only started to be unveiled in the late 2000's and are still poorly understood. Here, we introduce how Tduanyu1842N7 was first highlighted has a protein mutated in some forms of X-linked mental retardation, which was later proposed to be caused by defects in neuronal morphogenesis and synaptic transmission. We then discuss the impacts Tduanyu1842N7 has on cell morphology of dendritic cells and osteoclasts, through rearrangement of actin cytoskeleton and how Tduanyu1842N7 was shown to be a target of autoantibody in patients suffering from type 1 diabetes. Finally, we are addressing the double edge sword that is Tduanyu1842N7 in cancer. In the second part of this review, we address the known roles of Tduanyu1842N6 and how this protein was shown to participate in synaptic transmission and in amyloid precursor protein secretion, which may contribute to Alzheimer's disease pathology. We conclude this review by discussing the anti-inflammatory effect of

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