Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression.
Exp Biol Med (Maywood). 2020 Jun;245(12):1009-1015. doi:10.1177/1535370220927996. Epub 2020 May 25
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摘要
IMPACT study explored the role of ribophorin II (RPN2) in myelodysplastic syndromes (MDSs) cell proliferation and growth and revealed that RPN2 knockdown suppressed OCI-AML3 cell growth and proliferation and triggered cell cycle arrest and elicited apoptosis in OCI-AML3 cells. In addition, it shed light on the etiology of RPN2's role in MDS cell proliferation that RPN2 can negatively impact enhancer of zeste homolog-2 (EZH2) expression, which in turn is able to modulate the cell cycle location and death in OCI-AML3 cells. Hence, RPN2 expression could be a latent predictor of prognosis in patients with MDS.
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基因功能
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原始数据
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文献解读
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