[No authors listed]
Folate receptor alpha (FOLR1), a glycosylphosphatidylinositol-linked protein, is a well characterized folate transporter. However, the prognostic power of FOLR1 in cancer remains controversial. We conducted a meta-analysis to assess the prognostic roles of FOLR1 on different cancers. Twelve studies involving 4471 patients were included in this meta-analysis. The pooled analysis indicated that high FOLR1 significantly predicted poor overall survival (OS) (pooled hazard ratio (HR)â=â0.78, 95% confidence interval (CI)â=â0.64-0.94, pâ=â0.009) and the disease-free survival (DFS) (HRâ=â1.25, 95% CIâ=â1.07-1.47, pâ=â0.005). Subgroup analyses based on tumour type found that high FOLR1 level was associated with poor OS in breast cancer (HRâ=â2.66, 95% CIâ=â1.54-4.59, pâ=â0.0005) and endometrial carcinoma (HRâ=â1.30, 95% CIâ=â1.05-1.61, pâ=â0.02). However, FOLR1 has relatively weakly correlation with gender, tumour size and chemotherapy. Additionally, overexpression of FOLR1 was correlated with grade, FIGO stage, vital status and nodule status. The present meta-analysis indicated that the high expression of FOLR1 is associated with the poor survival of cancer patients, which is helpful for the clinical decision-making process.
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