Investigation of Kisspeptin Role in Experimental Kidney Ischemia/Reperfusion Injury.
[No authors listed]
摘要
INTRODUCTION:Kisspeptin is biologically active peptide encoded by the KISS1 gene that is structurally found in the kidney tubule, collecting duct and vein smooth muscle cells. AIM:We aimed to investigate the role of kisspeptin in kidney function and renal pathophysiology in experimental kidney ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS:Male Spraque-Dawley rats were divided into control and I/R groups (n=8). Both kidney vessels of I/R group rats were clamped and subjected to ischemia for 60 minutes and reperfusion for 48 hours. After the reperfusion period blood samples and kidney tissue were collected under anesthesia. RESULTS:Levels of urea, creatinine (. CONCLUSIONS:The present study has shown that the levels of kisspeptin change in kidney damage and thus the kisspeptin may play a role in the regulation of renal function and in the pathophysiology of acute kidney injury.
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基因功能
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原始数据
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文献解读
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