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m6A RNA methylation regulators correlate with malignant progression and have potential predictive values in clear cell renal cell carcinoma.

Exp Cell Res. 2020 Jul 01;392(1):112015. Epub 2020 Apr 22
Qi-Jie Zhang 1 , Jiao-Chen Luan 1 , Le-Bin Song 2 , Rong Cong 1 , Chen-Jian Ji 1 , Xiang Zhou 1 , Jia-Dong Xia 3 , Ning-Hong Song 4
Qi-Jie Zhang 1 , Jiao-Chen Luan 1 , Le-Bin Song 2 , Rong Cong 1 , Chen-Jian Ji 1 , Xiang Zhou 1 , Jia-Dong Xia 3 , Ning-Hong Song 4
+ et al

[No authors listed]

Author information
  • 1 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • 2 Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • 3 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: dongjiaxianjmu@sina.com.
  • 4 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: songninghong_urol@163.com.

摘要


N6-methyladenosine (m6A) has been reported to be involved in several biological processes in tumors. In this study, we found that most of the m6A RNA methylation regulators were not only differentially expressed between clear cell renal cell carcinoma (ccRCC) and normal but also among ccRCC stratified by different clinicopathologic characters. Two ccRCC subgroups, cluster 1 and 2, were identified using consensus clustering based on the expression of m6A methylation regulators. Although no obvious differences were observed between two subgroups regarding clinicopathologic characters, except gender, patients in cluster 1 had a relatively more favorable survival rate than cluster 2. Moreover, we established a risk signature with two m6A methylation regulators, METTL3 and METTL14, which was not only of great value for prognosis prediction but also closely associated with clinicopathological features. In conclusion, m6A RNA methylation regulators play an important role in ccRCC progression and are potentially favorable for prognostic stratification.

KEYWORDS: Clear cell renal cell carcinoma, Consensus clustering, Prognosis, Progression, m6A RNA methylation