[No authors listed]
There is extensive evidence suggesting that microRNAs (miRs) can modulate the activity of oncogenes and tumor suppressors, and are associated with the occurrence of cancer. In the present study, the function of miRâ363â3p in the progression of retinoblastoma (RB) was investigated. miRâ363â3p expression in RB was decreased, and miRâ363â3p protein levels were found to be inversely correlated with phosphatidylinositolâ4,5âbisphosphate 3âkinase catalytic subunit α (PIK3CA) levels. Overexpression of miRâ363â3p in an in vitro model of RB revealed that miRâ363â3p had anticancer effects on RB and regulated PIK3CA, pyruvate dehydrogenase kinase 1 (PDK1) and phosphorylated protein kinase B (pâAKT) protein expression. Downregulation of miRâ363â3p promoted cell proliferation of RB cells through PIK3CA, PDK1 and pâAKT protein expression. Knockdown of PIK3CA increased the anticancer effects of miRâ363â3p in RB cells. Treatment with OSUâ03012, a PDK1 inhibitor, accelerated the anticancer effects of miRâ363â3p in RB cells. Taken together, the results demonstrate that miRâ363â3p functions as a tumor suppressor in RB by targeting PIK3CA.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
{{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} |
{{ list.authorName }} {{ list.authorName }} |