例如:"lncRNA", "apoptosis", "WRKY"

Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia.

Stem Cell Reports. 2020 May 12;14(5):818-827. Epub 2020 Apr 16
Joel H L Tan 1 , Heike Wollmann 2 , Ans M M van Pelt 3 , Philipp Kaldis 2 , Daniel M Messerschmidt 4
Joel H L Tan 1 , Heike Wollmann 2 , Ans M M van Pelt 3 , Philipp Kaldis 2 , Daniel M Messerschmidt 4

[No authors listed]

Author information
  • 1 Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore 119077, Singapore.
  • 2 Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • 3 Center for Reproductive Medicine, Amsterdam Research Institute Reproduction and Development, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
  • 4 Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore. Electronic address: danielm@imcb.a-star.edu.sg.

摘要


Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the cost of self-renewal.

KEYWORDS: KAP1, TRIM28, fertility, haploinsufficiency, infertility, spermatogenesis, spermatogonial stem cells