例如:"lncRNA", "apoptosis", "WRKY"

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis.

Biosci Rep. 2020 May 29;40(5)
Shengli Li 1 , Wenwen Guo 1 , Huayun Geng 2 , Chao Wang 3 , Shuige Yang 1 , Xinxin Xu 4
Shengli Li 1 , Wenwen Guo 1 , Huayun Geng 2 , Chao Wang 3 , Shuige Yang 1 , Xinxin Xu 4
+ et al

[No authors listed]

Author information
  • 1 Department of Hematology, Jining No.1 People's Hospital, No. 6 Health Road, Rencheng District, Jining 272100, Shandong, China.
  • 2 Department of Hematology, Dongchangfu People's Hospital of Liaocheng, 281 Dongguan Street, Dongchangfu District, Liaocheng 252000, Shandong, China.
  • 3 Department of Emergency, Zi Bo Central Hospital, 54 Communist Youth League West Road, Zhangdian District, Zibo 255000, Shandong, China.
  • 4 Department of Hematology, Zi Bo Central Hospital, 54 Communist Youth League West Road, Zhangdian District, Zibo, 255000 Shandong, China.

摘要


T-cell acute lymphoblastic leukemia (T-ALL) is a malignant disease arising from the abnormal proliferation of T lymphocyte in marrow. Long non-coding RNAs (lncRNAs) are one kind of non-coding RNAs (ncRNAs), which were reported to modulate the initiation or progression of diverse cancers. However, the role of LINC00511 in T-ALL was unknown. To figure out the function and mechanism of LINC00511 in T-ALL, a series of experiments were carried out. Based on the experimental results, we discovered that LINC00511 boosted cell proliferation and invasion, but hindered cell apoptosis in T-ALL cells. Besides, based on bio-informatics tool, miR-195-5p was selected for further exploration. Then, miR-195-5p was validated to bind with LINC00511. Hereafter, LRRK1 was testified to serve as a target gene of miR-195-5p. At last, rescue assays suggested that LRRK1 overexpression restored sh-LINC00511#1-mediated effects on cell proliferation and apoptosis. All in all, LINC00511 exacerbated T-ALL progression via miR-195-5p/LRRK1 axis, implying a potential therapeutic clue for the patients with T-ALL. © 2020 The Author(s).

KEYWORDS: LINC00511, LRRK1, T-cell acute lymphoblastic leukemia, miR-195-5p