例如："lncRNA", "apoptosis", "WRKY"

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population.

Genes (Basel). 2020 Mar 22;11(3)
Omar Graciano-Machuca 1 , Anabell Alvarado-Navarro 2 , María Guadalupe Ramírez-Dueñas 3 , Delfina Guadalupe Villanueva-Quintero 4 , Erandi Enif Velarde-de la Cruz 5 , Andrea Carolina Machado-Sulbarán 5 , Margarita Montoya-Buelna 3 , Pedro Ernesto Sánchez-Hernández 3
Omar Graciano-Machuca 1 , Anabell Alvarado-Navarro 2 , María Guadalupe Ramírez-Dueñas 3 , Delfina Guadalupe Villanueva-Quintero 4 , Erandi Enif Velarde-de la Cruz 5 , Andrea Carolina Machado-Sulbarán 5 , Margarita Montoya-Buelna 3 , Pedro Ernesto Sánchez-Hernández 3
+ et al

[No authors listed]

Author information
  • 1 Laboratory of Biological Systems, Department of Health Sciences, University Center of the Valleys (CUVALLES), UDG, Ameca, Jal. 4660, Mexico.
  • 2 Research Center in Immunology and Dermatology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico.
  • 3 Laboratory of Immunology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico.
  • 4 Inflammatory Diseases Care Center, Guadalajara, Jal. 44630, Mexico.
  • 5 Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico.

摘要

NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1/HLA-A (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1/HLA-Bw4 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1/HLA-A genotype in PsV pathology.

KEYWORDS: HLA, HLA-Bw4, KIR, KIR3DS1, psoriasis vulgaris

© 2017 biocloud.net版权所有 ICP证：京10042835号