例如:"lncRNA", "apoptosis", "WRKY"

Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.

Exp Biol Med (Maywood). 2020 Nov;245(17):1584-1593. doi:10.1177/1535370220914253. Epub 2020 Mar 25
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摘要


IMPACT increasing evidence implicating the important role of TDP-43 in the pathogenesis of a wide range of age-related neurodegenerative diseases, there is limited study of TDP-43 proteinopathy and its association with mitochondria during normal aging. Our findings of cytoplasmic accumulation of TDP-43 that is highly colocalized with mitochondria in neurons in selective brain regions in young animals in the absence of neuronal loss provide a novel insight into the development of TDP-43 proteinopathy and its contribution to neuronal loss.

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原始数据


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