例如:"lncRNA", "apoptosis", "WRKY"

A CD24-p53 axis contributes to African American prostate cancer disparities.

Prostate. 2020 May;80(8):609-618. doi:10.1002/pros.23973. Epub 2020 Mar 13
Wei Liu 1 , Yue Zhang 1 , Shi Wei 2 , Sejong Bae 3 , Wei-Hsiung Yang 4 , Gary J Smith 5 , James L Mohler 5 , Elizabeth T H Fontham 6 , Jeannette T Bensen 7 , Guru P Sonpavde 8 , Guo-Yun Chen 9 , Runhua Liu 1 , Lizhong Wang 1
Wei Liu 1 , Yue Zhang 1 , Shi Wei 2 , Sejong Bae 3 , Wei-Hsiung Yang 4 , Gary J Smith 5 , James L Mohler 5 , Elizabeth T H Fontham 6 , Jeannette T Bensen 7 , Guru P Sonpavde 8 , Guo-Yun Chen 9 , Runhua Liu 1 , Lizhong Wang 1
+ et al

[No authors listed]

Author information
  • 1 Department of Genetics and O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama.
  • 2 Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
  • 3 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
  • 4 Department of Biomedical Sciences, Mercer University, Savannah, Georgia.
  • 5 Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • 6 School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
  • 7 Lineberger Comprehensive Cancer Center and Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 8 Dana-Farber Cancer Institute, Boston, Massachusetts.
  • 9 Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

摘要


BACKGROUND:Using a functional analysis of prostate cancer cells, we found a CD24-dependent inactivation of mutant p53, but the clinical significance of this observation remained uncertain. Here, we validated these results with samples of human prostate cancer and explored the role of a CD24-p53 axis in racial disparities of prostate cancer. METHODS:Samples of formalin-fixed, paraffin-embedded prostate cancer from 141 European Americans (EAs) and 147 African Americans (AAs) in two independent sample cohorts were assessed for protein expression of CD24, mutant p53, mouse double minute 2 human homolog (MDM2), and cyclin dependent kinase inhibitor 2A (ARF) using immunohistochemical analyses. All samples were analyzed for TP53R175H and TP53R273H . RESULTS:CD24, mutant p53, MDM2, and ARF proteins were expressed in 55%, 24%, 39%, and 68% of prostate cancer samples, respectively. CD24 and mutant p53 were present more frequently in late-stage and metastatic prostate cancer. The presence of CD24 was associated with a greater than fourfold risk of metastasis, which included lymph node and distant metastases. H score analysis showed positive correlations of CD24 expression with mutant p53 (r = .308, P < .001) and MDM2 (r = .227, P = .004). There was a negative correlation for CD24 with ARF (r = -.280, P < .001). A racial disparity was evident for CD24 (AAs/EAs: 64% vs 47%; P = .004) but not for mutant p53 (AA/EA: 28% vs 21%; P = .152). In 32 CD24+ /mutant p53+ cases, a TP53R273H mutation was found in five cases, but no TP53R175H mutation was found. CONCLUSION:The CD24-p53 axis may contribute to aggressive and metastatic prostate cancers, especially those of AAs. This observation enhances understanding of the pathogenesis of prostate cancer and its associated racial disparities. © 2020 Wiley Periodicals, Inc.

KEYWORDS: CD24, TP53, metastasis, prostate cancer, racial disparity