TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy.

Tetraspanin 8 is a member of the tetraspanin superfamily that forms protein complexes by interacting with themselves and other various cellular signaling molecules. These protein complexes help build tetraspanin-enriched microdomains (TEMs) that efficiently mediate intracellular signal transduction. In physiological conditions, plays a vital role in the regulation of biological functions, including leukocyte trafficking, angiogenesis and wound repair. Recently, reports have increasingly shown the functional role and clinical relevance of Tduanyu1842N8 overexpression in the progression and metastasis of several cancers. In this review, we will highlight the physiological and pathophysiological roles of Tduanyu1842N8 in normal and cancer cells. Additionally, we will cover the current status of monoclonal antibodies specifically targeting Tduanyu1842N8 and the importance of Tduanyu1842N8 as an emerging therapeutic target in cancers for monoclonal antibody therapy.

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