Comprehensive evaluation of SPATS2 expression and its prognostic potential in liver cancer.

Spermatogenesis associated serine rich 2 has been reported to be dysregulated in few types of cancer; however, no reports have investigated in liver cancer. The aim of the present study was to investigate duanyu1842TS2 expression in liver cancer and to analyze its association with the prognosis of liver cancer patients.We examined the differential expression of duanyu1842TS2 in liver cancer by exploring The Cancer Genome Atlas (TCGA) database. The diagnostic efficiency of duanyu1842TS2 was obtained by Receiver Operating Characteristic (ROC) curve. The Chi-Squared test was used to assess clinical relevance. Survival analysis and Cox regression model were used to detect the effect of duanyu1842TS2 on the survival of liver cancer patients. Gene Set (GSEA) was used to identify signaling pathways related to duanyu1842TS2 is highly expressed in liver cancer (P < 2.2e-16) and has the high diagnostic ability (AUC = 0.964). Survival analysis showed that patients with high duanyu1842TS2 expression have an apparently shorter overall survival (OS, P < .0001) and relapse-free survival (RFS, P < .0001). Cox regression analysis showed that high duanyu1842TS2 expression might be an independent risk factor for liver cancer (OS, HR = 2.41, P = .000; RFS, HR = 1.90, P < .001). GSEA analysis identified 3 signaling pathways (Mitotic spindle, G2 M checkpoint, E2F targets) that were enriched in the presence of high duanyu1842TS2 expression.duanyu1842TS2 expression could be a novel diagnostic and prognostic biomarker in liver cancer.

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