Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype-dependent manner.
Microbiol Immunol. 2020 Aug;64(8):574-577. doi:10.1111/1348-0421.12784. Epub 2020 Jul 03
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摘要
Previously, it was found that the hepatitis C virus NS5A interacted with ACBD3 in a genotype-dependent manner. However, the region in NS5A responsible for association with ACBD3 is not clear. Domain I of NS5A was identified as critical for ACBD3 binding. By comparing the differences of amino acids in domain I from different genotypes of NS5A, it was found that key amino acids potentially corresponded to the affinity of the NS5A-ACBD3 interaction. The findings not only revealed that domain I of NS5A associates with ACBD3 but they also shed mechanistic light on how NS5A is associated with ACBD3 in a genotype-dependent manner.
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基因功能
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原始数据
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文献解读
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