SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.

Leukemia. 2020 Sep;34(9):2525-2530. Epub 2020 Feb 19

Shalini Singh ¹ , Doaa Ahmed ² , Hamid Dolatshad ¹ , Dharamveer Tatwavedi ¹ , Ulrike Schulze ³ ,

Shalini Singh ¹ , Doaa Ahmed ² , Hamid Dolatshad ¹ , Dharamveer Tatwavedi ¹ , Ulrike Schulze ³ , Andrea Sanchi ¹ , Sarah Ryley ⁴ , Ashish Dhir ⁵ , Lee Carpenter ⁶ , Suzanne M Watt ⁶ , David J Roberts ⁷ , Amal M Abdel-Aal ² , Sohair K Sayed ² , Somaia A Mohamed ² , Anna Schuh ⁸ , Paresh Vyas ⁹ , Sally Killick ¹⁰ , Andriana G Kotini ¹¹ , Eirini P Papapetrou ¹¹ , Daniel H Wiseman ¹² , Andrea Pellagatti ¹³ , Jacqueline Boultwood ¹⁴

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Author information

¹ Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
² Clinical Pathology Department, Assiut University, Assiut, Egypt.
³ Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
⁴ Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, The Churchill Hospital, Oxford, UK.
⁵ Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
⁶ Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
⁷ National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK.
⁸ Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, UK.
⁹ Haematology Theme Oxford Biomedical Research Centre and Department of Hematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
¹⁰ Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
¹¹ Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹² Division of Cancer Sciences, University of Manchester, Manchester, UK.
¹³ Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. andrea.pellagatti@ndcls.ox.ac.uk.
¹⁴ Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. jacqueline.boultwood@ndcls.ox.ac.uk.

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