Molecular Regulation of Notch Signaling by Gremlin.

Adv. Exp. Med. Biol.2020;1227:81-94. doi:10.1007/978-3-030-36422-9_6

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Gremlin is a member of the TGF-Î² superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin-VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.

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Molecular Regulation of Notch Signaling by Gremlin.

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