Structural basis for RNA polymerase III transcription repression by Maf1.

Nat Struct Mol Biol. 2020 Mar;27(3):229-232. Epub 2020 Feb 17

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摘要

Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences phenotypes ranging from metabolic efficiency to lifespan. Here, we present a 3.3-Ã-resolution cryo-EM structure of yeast Maf1 bound to Pol III, establishing that Maf1 sequesters Pol III elements involved in transcription initiation and binds the mobile C34 winged helix 2 domain, sealing off the active site. The Maf1 binding site overlaps with that of TFIIIB in the preinitiation complex.

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Structural basis for RNA polymerase III transcription repression by Maf1.

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