[No authors listed]
To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifically, the minor allele C of rs2525885 and allele A of rs2839698 was associated with elevated EOC genetic susceptibility under both dominant and recessive models (TCÂ +Â CC vs TT: adjusted OR: 1.61, PÂ =Â .031; CC vs TTÂ +Â TC: adjusted OR: 4.87, PÂ =Â .014; GAÂ +Â AA vs GG: adjusted OR: 1.63, PÂ =Â .023; AA vs GGÂ +Â GA: adjusted OR: 2.43, PÂ =Â .007). For rs3741206, the genotype TCÂ +Â CC was associated with a significant decrease in EOC risk with the TT genotype as reference in a dominant genetic model (adjusted OR: 0.44, PÂ =Â .003), while for rs3741219, genotype AA was associated with a 59% decrease in EOC risk only in the recessive model (adjusted OR: 0.41, PÂ =Â .038). In the stratified analysis, an increased risk associated with the variant genotypes was observed in only subjects aged >47Â years for rs2525885 (adjusted ORÂ =Â 2.04, PÂ =Â .024), rs2839698 (adjusted ORÂ =Â 2.50, PÂ =Â .047) and rs3741206 (adjusted ORÂ =Â 0.37, PÂ =Â .009), respectively. What's more, the TCÂ +Â CC genotype of rs2525885 was significantly associated with advanced FIGO stage (III vs II, adjusted ORÂ =Â 2.73, PÂ =Â .040).
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