Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.
Nat Neurosci. 2020 Apr;23(4):481-486. Epub 2020 Feb 10
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摘要
Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.
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基因功能
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原始数据
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文献解读
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